Here at Gecko Joint & Spine we stay on top of all the research being done on Platelet Rich Plasma. Here is a collection of the most relevant and the most recent research.
Steve Sampson, DO
Game-Changer: Ultrasound-guided needle procedures offer accurate, cost-effective, and often less painful treatment of musculoskeletal disorders
Imaging Economics, September 2011, Dollars & Sense.
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Steven Sampson DO, Michael Meng DC, Adam Schulte OMS III, Drew Trainor MS/OMS III, Roberto Montenegro PhD, Danielle Aufiero MD
Management of Dupuytren Contracture With Ultrasound-Guided Lidocaine Injection and Needle Aponeurotomy Coupled With Osteopathic Manipulative Treatment
JAOA. February 2011, Vol 111, No 2.
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Steven Sampson, Danielle Aufiero, Michael Meng, Anthony Bledin, Terry Gillette, Mona Zall
Platelet-rich plasma therapy as a first-line treatment for severe Achilles tendon tear: a case report
International Journal of Therapy and Rehabilitation. February 2011, Vol 18, No 2.
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Steven E. Sampson DO, Marty Reed MD, Holly Silvers MPT, Michael Meng DC, Bert Mandelbaum MD.
Injection of Platelet-Rich Plasma in Patients with Primary and Secondary Knee Osteoarthritis: A Pilot Study
The American Journal of Physical Medicine & Rehabilitation. Nov 20, 2010 online. Print Dec 2010.
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Preparation of blood for PRP injectionReview Articles
Rosalyn T Nguyen MD, Joanne Borg-Stein MD, Kelly McInnis DO.
Applications of Platelet-Rich Plasma in Musculoskeletal and Sports Medicine: An Evidence-Based Approach
PM&R; 2011 Mar; 3(3): 226-250.
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Kenneth S Lee, John J Wilson, David P Rabago, Geoffrey S Baer, Jon A Jacobson, Camilo G Borrero.
Musculoskeletal Applications of Platelet-Rich Plasma: Fad or Future?
AJR Am J Roentgenol. 2011 Mar;196(3):628-36.
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Sampson S, Gerhardt M, Mandelbaum B.
Platelet rich plasma injection grafts for musculoskeletal injuries: a review
Curr Rev Musculoskelet Med. 2008 Dec;1(3-4):165-74.
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Tate K MD, Crane D.
Platelet Rich Plasma Grafts in Musculoskeletal Medicine
Journal of Prolotherapy. 2010 May; 2(2): 371-376.
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Crane D, Everts P.
Platelet Rich Plasma (PRP) Matrix Grafts. Practical Pain Management
2008:8 (1):11-26.
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Hall MP, Band PA, Meislin RJ, Jazrawi LM, Cardone DA.
Platelet-rich plasma: current concepts and application in sports medicine
J Am Acad Orthop Surg. 2009 Oct;17(10):602-8.
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Sánchez M, Anitua E, Orive G, Mujika I, Andia I.
Platelet-rich therapies in the treatment of orthopaedic sport injuries
Sports Med. 2009;39(5):345-54.
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Molloy T, Wang Y, Murrell G. 2003.
The Roles of Growth Factors in Tendon and Ligament Healing
Sports Med. 33(5):381-394
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Call Gecko Joint and Spine for a consultation to start PRP and begin the road back to a functioning and pain free life.
Human Studies: Tendon/Ligament
SHOULDER
Nickolas Garbis MD, Anthony A. Romeo MD, Geoffrey Van Thiel MD, MBA, Neil Ghodadra MD, Matthew T. Provencher MD, Brian J. Cole MD, MBA, Nikhil Verma MD
Clinical Indications and Techniques for the Use of Platelet-Rich Plasma in the Shoulder
Platelet-rich plasma (PRP) has recently been a topic of significant interest in the orthopedic community. In addition to the numerous basic science studies regarding the in vitro effects of PRP, there is more literature regarding the use of PRP in the clinical setting. PRP is …
Operative Techniques in Sports Medicine, Volume 19, Issue 3, September 2011, Pages 165-169.
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ELBOW
Allan Mishra MD, Taco Gosens MD, PhD
Clinical Indications and Techniques for the Use of Platelet-Rich Plasma in the Elbow
Platelet-rich plasma (PRP) is an emerging biological treatment option in sports medicine. Its value is best established for elbow-related disorders, such as lateral epicondylar tendinopathy. This common condition typically resolves with simple treatment modalities, …
Operative Techniques in Sports Medicine, 2011
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Finnoff JT, Fowler SP, Lai JK, Santrach PJ, Willis EA, Sayeed YA, Smith J.
Treatment of Chronic Tendinopathy with Ultrasound-Guided Needle Tenotomy and Platelet-Rich Plasma Injection
PM R. 2011 Aug 25. Epub ahead of print
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Taco Gosens MD/PhD, Joost C Peerbooms MD, Wilbert van Laar, Brenda L den Oudsten PhD.
Ongoing Positive Effect of Platelet-Rich Plasma Versus Corticosteroid Injection in Lateral Epicondylitis: A Double-Blind Randomized Controlled Trial With 2-Year Follow-Up
Am J Sports Med; 2011 Mar.
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Keith S Hechtman MD, John W Uribe MD, Angie Botto-Vandemen PhD, Gary M Kiebzak PhD
Platelet-rich Plasma Injection Reduces Pain in Patients With Recalcitrant Epicondylitis
Orthopedics, February 2011.
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Rabago D, Best TM, Zgierska AE, Zeisig E, Ryan M, Crane D
A systematic review of four injection therapies for lateral epicondylosis: prolotherapy, polidocanol, whole blood and platelet-rich plasma.
Br J Sports Med; 2009 Jul;43(7):471-81
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Alsousou J, Thompson M, Hulley P, Noble A, Willett K
The biology of platelet-rich plasma and its application in trauma and orthopaedic surgery: a review of the literature.
J Bone Joint Surg Br; 2009 Aug;91(8):987-96
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Hall MP, Band PA, Meislin RJ, Jazrawi LM, Cardone DA
Platelet-rich plasma: current concepts and application in sports medicine.
J Am Acad Orthop Surg; 2009 Oct;17(10):602-8
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Peerbooms, J. C., Sluimer, J., Bruijn, D. J., Gosens, T.
Positive Effect of an Autologous Platelet Concentrate in Lateral Epicondylitis in a Double-Blind Randomized Controlled Trial: Platelet-Rich Plasma Versus Corticosteroid Injection With a 1-Year Follow-up
Am J Sports Med 38: 255-262
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Mishra A, Pavelko T.
Treatment of chronic elbow tendinosis with buffered platelet-rich plasma
Am J Sports Med. 2006 Nov;34(11):1774-8.
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Edwards SG, Calandruccio JH.
Autologous blood injections for refractory lateral epicondylitis
Am J Hand Surg. 2003;28(2):272–8.
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Call Gecko Joint and Spine for a consultation to start PRP and begin the road back to a functioning and pain free life.
KNEE
Kon E, Mandelbaum B, Buda R, Filardo G, Delcogliano M, Timoncini A, Fornasari PM, Giannini S, Marcacci M
Platelet-Rich Plasma Intra-Articular Injection Versus Hyaluronic Acid Viscosupplementation as Treatments for Cartilage Pathology: From Early Degeneration to Osteoarthritis
Arthroscopy. 2011 Aug 8. (Epub ahead of print)
Biomechanics Laboratory-III Clinic, Rizzoli Orthopaedic Institute, Bologna, Italy.
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Park SI, Lee HR, Kim S, Ahn MW, Do SH
Time-sequential modulation in expression of growth factors from platelet-rich plasma (PRP) on the chondrocyte cultures
Mol Cell Biochem. 2011 Sep 29. (Epub ahead of print)
Department of Orthopedic Surgery, College of Medicine, Yeungnam University, Daegu, 705-717, Korea.
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Giuseppe Filardo, Elizaveta Kon, Stefano Della Villa, Ferruccio Vincentelli, Pier Maria Fornasari and Maurilio Marcacci
Use of platelet-rich plasma for the treatment of refractory jumper’s knee
International Orthopaedics; 31 July 2009; Vol 24, No 6; 909-915
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Elizaveta Kon, Giuseppe Filardo, Marco Delcogliano, Mirco Lo Presti, Alessandro Russo, Alice Bondi, Alessandro Di Martino, Annarita Cenacchi, Pier Maria Fornasari, Maurilio Marcacci
Platelet-rich plasma: New clinical application: A pilot study for treatment of jumper’s knee
International Journal of the Care of the Injured; 2009 June; 40(6): 509-603
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Kelly L. Scollon-Grieve, MD, Gerard A. Malanga, MD
Platelet-Rich Plasma Injection for Partial Patellar Tendon Tear in a High School Athlete: A Case Presentation
American Academy of Physical Medicine and Rehabilitation, Vol. 3, 391-395, April 2011.
[Full Article]
A knee injection under ultrasound guidance
Call Gecko Joint and Spine for a consultation to start PRP and begin the road back to a functioning and pain free life.
FOOT/ANKLE
Xiaofeng Jia MD, PhD, Paul G. Peters MD, Lew Schon MD
The Use of Platelet-Rich Plasma in the Management of Foot and Ankle Conditions
Platelet-rich plasma (PRP) contains growth factors derived from venous blood. Bone marrow concentrate (BMC) is an analogous platelet-rich product that is generated from bone marrow aspirate and might have the added advantage of containing mesenchymal stem cells. …
Operative Techniques in Sports Medicine, Volume 19, Issue 3, September 2011, Pages 177-184.
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Steven Sampson, Danielle Aufiero, Michael Meng, Anthony Bledin, Terry Gillette, Mona Zall
Platelet-rich plasma therapy as a first-line treatment for severe Achilles tendon tear: a case report
International Journal of Therapy and Rehabilitation. February 2011, Vol 18, No 2.
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Wiegerinck JI, Reilingh ML, de Jonge MC, van Dijk CN, Kerkhoffs GM
Injection Techniques of Platelet-Rich Plasma Into and Around the Achilles Tendon: A Cadaveric Study
Am J Sports Med, April 19 2011.
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Gaweda K.
Treatment of Achilles Tendinopathy with Platelet RichPlasma
International Journal of Sports Med, June 2010.
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P Robert J. de Vos et al.
Platelet-Rich Plasma Injection for Chronic Achilles Tendinopathy: A Randomized Controlled Study
JAMA 2010, 3003(2): 144-149.
[Full article]
Monto, R.
Platelet Rich Plasma (PRP) Effectively Treats Chronic Achilles Tendinosis
2010 Annual American Academy of Orthopaedic Surgeons meeting Podium Presentations.
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O’ Malley M.
Platelet-rich plasma (PRP) in managing Achilles tendinosis
2010 Annual American Orthopaedic Foot & Ankle Society (AOFAS) Meeting.
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Filardo, G, Lo Presti M, Kon E, Marcacci M. 2010.
Nonoperative Biological Treatment Approach for partial Achilles Tendon Lesion
Orthopedics 1;33(2):120-3.
[Full article]
Barrett S, Erredge S.
Growth factors for chronic plantar fasciitis
Podiatry Today 2004;17:37.
[Full article]
Human Studies: Muscle
Hector A. Mejia MD, James P. Bradley MD
The Effects of Platelet-Rich Plasma on Muscle: Basic Science and Clinical Application
Muscle injuries are the most common type of injuries in sports. The natural course in this repair process is often slow, incomplete, and unpredictable. For competitive or professional athletes, this delay or unpredictability in complete healing may be costly or career ending. …
Operative Techniques in Sports Medicine, Volume 19, Issue 3, September 2011, Pages 149-153.
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Hammond JW, Hinton RY, Curl LA, Muriel JM, Lovering RM
Use of autologous platelet-rich plasma to treat muscle strain injuries.
Am J Sports Med; 2009 Jun;37(6):1135-42
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Nikolidakis D, Jansen JA
The biology of platelet-rich plasma and its application in oral surgery: literature review.
Tissue Eng Part B Rev; 2008 Sep;14(3):249-58
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Borrione, Paolo MD; Gianfrancesco, Alessia Di PharmD; Pereira, Maria Teresa MD; Pigozzi, Fabio MD
Platelet-Rich Plasma in Muscle Healing
American Journal of Physical Medicine & Rehabilitation: October 2010 – Volume 89 – Issue 10 – pp 854-861.
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Mishra A, Woodall Jr. J, Vieira A. 2009.
Treatment of Tendon and Muscle Using Platelet-Rich Plasma
Clin Sports Med 28(1): 113-25.
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Carpenter, T et al.
Treatment of muscle injuries by local administration of autologous conditioned serum: a pilot study on sportsmen with muscle strains
Int J Sports Med, 2004. 25:589-594.
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Hammond, JW et al.
Use of autologous platelet-rich plasma to treat muscle strain injuries
American Journal of Sports Med, 2009. 37 (6): 1135-1142.
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Human Studies: Arthritis/Cartilage
Lisa A. Fortier DVM, PhD, Catherine H. Hackett DVM, PhD, Brian J. Cole MD, MBA
The Effects of Platelet-Rich Plasma on Cartilage: Basic Science and Clinical Application
Platelet-rich plasma (PRP) is emerging as a biological therapy for the treatment of cartilage injuries and for intra-articular application to address knee pain. Basic science studies indicate that PRP stimulates cell proliferation and the production of cartilage matrix by chondrocytes and …
Operative Techniques in Sports Medicine, Volume 19, Issue 3, September 2011, Pages 154-159.
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Gerben M. van Buul, MD, Wendy L.M. Koevoet, BSc, Nicole Kops, BSc, P. Koen Bos, MD, PhD, Jan A.N. Verhaar, MD, PhD, Harrie Weinans, PhD, Monique R. Bernsen, PhD, Gerjo J.V.M. van Osch, PhD
Platelet-Rich Plasma Releasate Inhibits Inflammatory Processes in Osteoarthritic Chondrocytes
The American Journal of Sports Medicine; August 19, 2011
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Sampson, S.
Injection of Platelet-Rich Plasma in Patients with Primary and Secondary Knee Osteoarthritis: A Pilot Study
American Journal of Physical Medicine & Rehabilitation. Nov 20, 2010 online, Dec 2010 print. 961-969.
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Ana Wang-Saegusa, Ramón Cugat, Oscar Ares, Roberto Seijas, Xavier Cuscó and Montserrat Garcia-Balletbó.
Infiltration of plasma rich in growth factors for osteoarthritis of the knee short-term effects on function and quality of life
Archives of Orthopaedic and Trauma Surgery, Volume 131, Number 3, 311-317, DOI: 10.1007/s00402-010-1167-3.
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Hunziker EB, Driesang IM, Morris EA. Clinical orthopaedics and related research.
Chondrogenesis in cartilage repair is induced by members of the transforming growth factor-beta superfamily
Clin Orthop Relat Res. 2001;391(Suppl):S171–81.
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Nakagawa K, Sasho T, Arai M, Kitahara S, Ogino S, Wada Y, et al.
Effects of autologous platelet-rich plasma on the metabolism of human articular chondrocytes
Chiba and Ichihara, Japan. Electronic poster presentation P181. International Cartilage Repair Society Meeting, Warsaw Poland, October 2007.
Kon E, Filardo G, Presti ML, Delcogliano M, Iacono F, Montaperto C, et al.
Utilization of platelet-derived growth factors for the treatment of cartilage degenerative pathology
Bologna, Italy. Electronic poster presentation 29.3. International Cartilage Repair Society Meeting, Warsaw Poland, October 2007.
Anitua E, Sanchez M, Nurden AT, Zalduendo MM, De La Fuente M, Azofra J, et al.
Platelet-released growth factors enhance the secretion of hyaluronic acid and induce hepatocyte growth factor production by synovial fibroblasts from arthritic patients
Rheumatology. 2007;46(12):1769–72.
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Kon E, Buda R, Mandelbaum B, Filardo G, Timoncini A, Delcogliano M, Fornasari P, Giannini S, Marcacci M.
PRP intra-articular injection versus viscosupplementation as treatments for early osteoarthritis
Podium Presentation, # 685. American Academy of Orthopaedic Surgeons, New Orleans LA. March 12, 2010.
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Wu W, Zhang J, Dong Q, Liu Y, Mao T, Chen F
Platelet-rich plasma – A promising cell carrier for micro-invasive articular cartilage repair. [Journal Article, Research Support, Non-U.S. Gov't]
Med Hypotheses 2009 Apr; 72(4):455-7.
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Sun, Y et al.
The regenerative effect of platelet-rich plasma on healing in large osteochondral defects
International Orthopaedics, 2010. 34:589-597.
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Elizaveta Kon, Roberto Bnda, Ginseppe Filardo, Alessandro Di Martino, Antonio Timoncini, Annarita Cenacchi, Pier Maria Fornasari, Sandro Giannini, Maurilio Marcacci.
Platelet-rich plasma: intra-articular knee injections produced favorable results on degenerative cartilage lesions
Knee Surg Sports Traumatol Arthrosc. Sept 2009: 0940-8.
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Nathan Wei.
Tissue Engineering with Platelet-Rich Plasma and Stem Cells: New Frontier In Rheumatology
The Journal of Musculoskeletal Medicine. July 2009.
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Sanchez M, Azofra J, Anitua E, Andia I, Padilla S, Santisteban J, Mujika I (2003).
Plasma rich in growth factors to treat an articular cartilage avulsion: a case report
Med Sci Sports Exerc 35:1648-1652.
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Berghoff W, Pietrzak W, Rhodes R.
Platelet-rich plasma application during closure following total knee arthroplasty
Orthopedics. 2006;29(7):590–8.
[Full article]
Gardner MJ, Demetrakopoulos D, Klepchick P, Mooar P.
The efficacy of autologous platelet gel in pain control and blood loss in total knee arthroplasty: an analysis of the haemoglobin, narcotic requirement and range of motion
Int Orthop. 2006;31:309–13.
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Everts P, Devilee R, Mahoney C, Eeftinck-Schattenenkerk M, Knape J, Van Zundert A.
Platelet gel and fibrin sealant reduce allogeneic blood transfusions in total knee arthroplasty
Acta Anaesthesiol Scand. 2006;50:593–9.
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Call Gecko Joint and Spine for a consultation to start PRP and begin the road back to a functioning and pain free life.
Animal Studies
Geng Z, Wang C, Zhou H
Effect of platelet-rich plasma on tendon healing
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. Mar 2011; 25(3):344-8.
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Harris, N. Lindsay, MD; Purnell, Mark L., MD; Huffer, William E., MD; Larson, Andrew I.
The Effect of Platelet-Rich Plasma (PRP) on Normal Soft Tissues in the Rabbit BSME
Phinney, Shawn, MA; Von Stade, Eleanor F., MD. Aspen Orthopaedics Associates and Aspen Sports Medicine Foundation (AMSF).
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Wu W, Chen F, Liu Y, Ma Q, Mao T
Autologous injectable tissue-engineered cartilage by using platelet-rich plasma: experimental study in a rabbit model. [Journal Article, Research Support, Non-U.S. Gov't]
J Oral Maxillofac Surg 2007 Oct; 65(10):1951-7.
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Bir SC, Esaki J, Marui A, Yamahara K, Tsubota H, Ikeda T, Sakata R
Angiogenic properties of sustained release platelet-rich plasma: characterization in-vitro and in the ischemic hind limb of the mouse. [Comparative Study, In Vitro, Journal Article]
J Vasc Surg 2009 Oct; 50(4):870-879.e2.
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Aspenberg P, Virchenko O. 2004.
Platelet concentrate injection improves Achilles tendon repair in rats
Acta Orthop Scand 75(1):93-9.
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Taylor M, Norman T, Clovis N, Blaha D.
The response of rabbit patellar tendons after autologous blood injection
Med Sci Sports Exerc. 2002;34(1):70–3.
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Carpenter, T, et al.
Treatment of muscle injuries by local administration of autologous conditioned serum: animal experiments using a muscle contusion model
Int J Sports Med, 2004. 25:1-6.
[Download article]
Call Gecko Joint and Spine for a consultation to start PRP and begin the road back to a functioning and pain free life.
Human Studies: Spine
Adam D. Weglein
Focused Review: Current Trends in Platelet-Rich Plasma Injection Treatments
Journal of Neurosurgical Review, Vol 1 (2011).
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PRP Physiology
Eppley BL, Woodell JE, Higgins J
Platelet quantification and growth factor analysis from platelet-rich plasma: implications for wound healing
Plast Reconstr Surg. 2004 Nov;114(6):1502-8.
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Wang P, Qu Y, Man Y
Platelet-rich plasma as a scaffold for injectable soft-tissue augmentation. [JOURNAL ARTICLE]
Cytotherapy 2010 May 21.
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Call Gecko Joint and Spine for a consultation to start PRP and begin the road back to a functioning and pain free life.
